Japanese Scientists produced mice from two dads for the first time ever

Japanese Scientist have produced mice for two biologically male parents fore to he first time — a great achievement in reproductives Biology.

Katsuhiko Hayashi, the professor of genome department in University of Osaka, and his co-workers generated eggs from the skin of male parent of mice, and then implanted in the female mice, began to produce healthy but identical pups, according to the research reported by Journal Nature on 15 March.

How did they do it?

As reported by Journal Nature, this process wasn't easy. They fertilized 630 eggs to produce only 7 pups, that grew into healthy and fertile adults.

Let's illustrate this process deeply. The research team, led by Japanese Scientist Katsuhiko Hayashi, first took the cell from the skin of male mice, and then reprogrammed these cells to create egg cells.

The most notable thing is that they are always females. Infactt, they have two copies of 'X' chromosome in their 23rd pair. As we know, the male has one 'X' and one 'Y' chromosome, these cells can also be used to produce females after simple modifications.

The next step was to convince 'XX' cells to transform into egg cells.

They did this by using additional genetic technique which to vanishes 'Y' chromosome and duplicates the 'X' chromosome. After all, these cells are considered to be genetically female.

What might this mean for humans?

The research team who did it also emphasized that they are still far away for making it work in humans. After all, they would have to make sure that this modification does not create any harmful mutation elsewhere.

This technique could be helpful for those individuals and couples facing infertility.

Conservation of Endangered Species:

This technique holds the promise for the conservation of endangered species from being extinct. However, it is not yet confirmed that whether the spontaneous loss of 'Y' and duplication of 'X' chromosome in mice would be possible in other species, said Mike McGrew.

This technique developed by Katsuhiko Hayashi could be used to save northern white rhino because only two members of this specie have left in world and both are females.

However, Hildebrandt is trying to reproduce them by using sperm and tissue samples taken from departed male counterparts.

"This is technology for the future, but we have the opportunity to create a genetically healthy population. This is only possible with this stem cell approach" said Hildebrandt.

Conclusion:

In conclusion, the development of this technique  by Japanese scientists is a remarkable achievement that has significant implications for the future of reproductive technology. This breakthrough represents a major milestone in the field of assisted reproductive technology and challenges the traditional notion of biological reproduction.

The potential benefits of this technique are numerous, especially for same-sex couples who wish to have genetically related offspring. It also has the potential to benefit individuals who have fertility issues and cannot conceive naturally. 

However, there are still ethical and social considerations that need to be addressed before this technology can be widely adopted. This includes the potential risks associated with genetic manipulation, as well as the cultural and religious beliefs surrounding traditional notions of reproduction.

With further research and development, this breakthrough may provide new options for individuals and couples who face infertility issues and, of course, for the conservation of endangered species as well. Anyhow, careful consideration of the ethical and social implications is required to ensure that this technology is used safely and responsibly.